how long do venofer side effects last

(IV iron is absorbed by the body more rapidly than oral iron.) But keep in mind that in this study, delayed allergic reaction only occurred in one person. These changes could help improve your anemia on a long-term basis. Talk with the doctor. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Both Injectafer and Feraheme belong to a class of medications known as iron replacement products. These drugs have been compared in a clinical trial of adults with both IDA and CKD who didnt need dialysis. All rights reserved. Injectafer helps to treat IDA by providing an iron infusion directly into your body. Venofer is indicated to treat iron deficiency anemia (IDA) in adult and pediatric patients (2 years and older) with chronic kidney disease (CKD). "The most common side effects to COVID vaccines include pain at the injection site, fevers, chills, nausea, headaches, tiredness, and painful or swollen lymph nodes in the arm where the vaccine. People who are ongoingcancer treatmentwithradiation therapyor takingchemotherapy drugsmay be more susceptible toside effects. If you miss an appointment for your Injectafer dose, youll need to call your doctors office. (And Injectafer is used to treat IDA.) Laboratory tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be performed periodically to monitor your progress or check for side effects. Their medical staff can help you set up another time to receive your Injectafer dose. No, you dont need to follow a specific diet plan while youre using Injectafer unless your doctor recommends otherwise. Other drugs are available that can treat iron deficiency anemia (IDA). In this group, after 35 days of treatment: In clinical studies, Injectafer was effective in treating IDA in adults with CKD who didnt require dialysis. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. After receiving IV iron therapy, you will be monitored for 30 minutes to make sure you do not have an allergic reaction or a drop in blood pressure. Side effects like nausea and low blood pressure are common with most iron infusions. You must check to make sure that it is safe for you to take Venofer with all of your drugs and health problems. Here we look at how Injectafer and Venofer are alike and different. An example of a drug interaction that many people are not aware of isgrapefruitjuice and statins. Serious side effects should be reported to a physician and/or PharmD for medical advice. Change in taste. Many people using this medication do not have serious side effects. These effects typically last between 7 and 11 hours. These nutrients include iron, vitamin B12, and folate. Instead, youll start by receiving just one treatment course of Injectafer. 2 0 obj reactions at the site of the injection. Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. endobj Injectafer can cause low blood levels of phosphorus, which is a condition called hypophosphatemia. You may report side effects to FDA at 1-800-FDA-1088. This is not a complete list of side effects and others may occur. Medically reviewed by Sanjai Sinha, MD. There have also been reports of serious allergic reactions to Venofer. Ask your doctor or healthcare provider if Venofer is the right choice for you. Venofer (iron sucrose) injection, USP is an intravenous (IV) form of iron, which is a key ingredient for making new red blood cells. You are encouraged to report side effects to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. If you have questions about drinking alcohol while youre taking Injectafer, talk with your doctor. If youre taking iron pills, be sure to tell your doctor before starting Injectafer. Your healthcare provider will watch you closely for 30 minutes after each dose. administered at your doctors office or an infusion center. Symptoms of a severe allergic reaction can include: Because of the risk of allergic reaction with Injectafer, your healthcare professional will monitor you for at least 30 minutes after you get each dose of the drug. Click below for effective ways to alleviate the discomfort felt fromside effects and learn how to get a free Medication and Drug Reaction DNAReport. Constipation,dry mouth, headaches, upset stomach, and many othercommonside effectscan greatly affect peoples quality of life, though. Before taking Injectafer, talk with your doctor about your health history. Clinical trials showed that Injectafer is effective in increasing hemoglobin levels in people with iron deficiency anemia (IDA). If you are allergic to Venofer; any part of this medicine; or any other drugs, foods, or substances. Its not known for sure how often this condition occurred during clinical trials, or if it occurred at all during the trials. A healthcare provider will give you this injection. Your doctor will recommend whether you should stop taking your multivitamin or any other supplements. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Injectafer can cause mild or serious side effects. Find comprehensive medical information for Venofer intravenous on RxList including its uses, side effects, precautions, drug interactions, overdose, pill images & warnings . ByDr. Iron sucrose injection has a molecular weight of approximately 34,000 - 60,000 daltons and a proposed structural formula: These symptoms can include: While youre taking Injectafer, your doctor will monitor your phosphorus levels if youre at risk for hypophosphatemia. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. SIDE EFFECTS: In adult patients, the most common side effects (2%) include diarrhea, upset stomach, throwing up, headache, dizziness, hypotension, pruritus (itching), pain in extremity, arthralgia (joint pain), back pain, muscle cramp, injection site reactions, chest pain and peripheral edema (swelling). It will take about three weeks to feel the effects but your fatigue will disappear and you will feel like a new person. Patients with celiac disease (gluten intolerance). He is an Affiliate Specialist of the American College of Medical Genetics and Genomics(ACMG), an Associate of the American College of Preventive Medicine(ACPM), and a member of the National Society of Genetic Counselors(NSGC). signs of inflammation in the lining of your stomach --pain or swelling, bloating, nausea, vomiting, loss of appetite, diarrhea, fever. Severeside effectscan lead to injury or death -drowsinesscan cause a car accident or injury when operating heavymachinery. With anemia, you have a low level of red blood cells (RBCs) in your body. Your doctor will monitor your hemoglobin level to tell if Injectafer is working for you. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Find out what health conditions may be a health risk when taken with Venofer Vial 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. There isnt a known interaction between Injectafer and alcohol. In fact, Injectafer is meant for some people whose anemia didnt improve with iron pills or for people who had side effects from iron pills. Theyll recommend how to manage your condition. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. As with all medications, the cost of Injectafer can vary. Here are answers to some frequently asked questions about Injectafer. Most people do not know how long theirside effectswill last until they go through them. Call your doctor for instructions if you miss an appointment for your Venofer injection. So theres no recommended pediatric dosage for Injectafer. While this may seem like it would be out of a persons body quickly, the rate of it being broken down is much slower afterward. Below are examples of these side effects. People from different ethnic backgrounds process medications differently. US residents can call their local poison control center at 1-800-222-1222. WebMD does not provide medical advice, diagnosis or treatment. TheNational Instituteof Health (NIH) and the U.S. Food andDrug Administration(FDA) monitor theside effectsof new and approved medications to ensure safety. Dizziness. (A medication class describes a group of drugs that work in the same way.). But for other people, their anemia may come back after Injectafer treatment. Its responsible for carrying oxygen throughout your body. But so far I feel better than before the infusion. A variety of tests can diagnose iron deficiency anemia. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine. (A class of medications describes a group of drugs that work in the same way.). Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Dilute Venofer in a maximum of 250 mL of 0.9% NaCl. In pediatric patients the most common side effects (>2%) are headache, viral respiratory tract infection, peritonitis, upset stomach, throwing up, fever, dizziness, cough, arteriovenous fistula thrombosis, hypotension and hypertension (increased blood pressure). The drug helps increase your hemoglobin level back to a value thats within the normal range. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Venofer, or with both drugs (when taken individually). Cholesterolmedication may reduce the risk of a stroke but it can decrease the quality of life for some people but causingweight gain, dizziness, nausea, and musclepain. All patients receiving Venofer require periodic blood tests to monitor the amount of iron in the blood. Iron sucrose can make it harder for your body to absorb iron medications you take by mouth. The infusion will take between 15-30 minutes if it is given in. Learn about uses, cost, how it works, and more. Injectafer isnt known to interact with any other medications, herbs, supplements, or foods. If either is present, do not use the liquid. Innovators Monograph For this purpose, Injectafer is approved for use in adults who either: Venofer is also approved to treat IDA. If you have any of these health problems: Too much iron in your body or anemia from a cause other than low iron. We comply with the HONcode standard for trustworthy health information. This is only a brief summary of general information about this medicine. (Hemoglobin is a protein thats found in red blood cells.). This could happen because Injectafer helps increase their hemoglobin levels, but it doesnt address the underlying cause of their anemia. The actual price youll pay depends on your insurance plan and any copays, your location, and the pharmacy you use. For people weighing 50 kg (about 110 lb) or more, administer Injectafer in two doses of 750 mg, at least 7 days apart. Venofer treatment may be repeated if iron deficiency reoccurs. Your body then uses the iron from Injectafer to make hemoglobin and new RBCs. }|54U|O~?|_v;f\o^(W+/-|^)O65_)rd sm }[x[)y.z Wz?9_jV0ub,`g`s?oXOSp/Kgw$b!Vb$;IvBVR9n|\0ln=;/=,mgw@do,[";/8nJL{n}Bb-|^6[~>a_1H'^M:^vv=iM+x|+Y He said sometimes the reaction does show up after a few doses and unfortunately it takes longer to get over it. Injectafer contains the active drug ferric carboxymaltose, while Feraheme contains the active drug ferumoxytol. Allergic reactions typically occur the first time your body is exposed to a drug. However, many people have no side effects or only have minor side effects. If you have more questions about how Injectafer will affect your anemia, talk with your doctor. 1xo`[kg'#KS#.#`uv:PM1+Ob`>y/8:6Ghl:y9B+-,9m[ All of the people took iron by mouth for 2 weeks. Learn about the causes, symptoms, diagnosis, and treatment of this. 1 0 obj Venofer may reduce the absorption of iron preparations taken by mouth. Selected from data included with permission and copyrighted by First Databank, Inc. These lists dont include all possible side effects. With IDA, you have low hemoglobin levels. Potentialside effectsthat are usually mild may include, but are not limitedto: Theseside effectsmay not impact life too much and may only be temporary. upper respiratory infection. Precautions. And the drug has also been studied in children with IDA who have inflammatory bowel disease (IBD). Iron is a vital mineral in the body, central to transporting oxygen around the body in the hemoglobin. Common MRI side effects include dizziness, anxiety, headache, nausea, hearing loud noises, and feeling chilled or hot in the MRI scanner. <> Orofer S 100 Injection 1 Injection in 1 Packet 286 301 5% off. This is because alcohol reduces your bodys absorption of certain nutrients that are necessary to make red blood cells. It is given into a vein for a period of time. Symptoms of overdosage include drowsiness, mental confusion, dizziness, diarrhea and vomiting etc. Side effects: DayQuil can cause side effects such as drowsiness, dizziness, nausea, vomiting, and stomach upset. These side effects may include constipation and diarrhea. Its because everyones body is different. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. Then the study was split into the following two groups, which are discussed below. Your doctor will do laboratory tests to monitor your response. This treatment course is split into two doses of the drug, which are given at least 7 days apart. Side effects are uncomfortable reactions to medications or drugs. Common Venofer side effects may include: fever, cold or flu symptoms ( sore throat, cough, stuffy nose, sneezing); high or low blood pressure; headache, dizziness; nausea, vomiting, diarrhea; muscle or joint pain, back pain; pain or swelling in an arm or leg; itching; or bruising or irritation where the medicine was injected. What should I know regarding pregnancy, nursing and administering Venofer Vial to children or the elderly. Weight changes may be due to symptoms of anemia improving. You should not receive Venofer if you have known allergies to iron sucrose. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. (See also Notes section.). Heres some detail on certain side effects this drug may cause. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. Which tests can diagnose iron deficiency anemia? Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft). For more information about taking Injectafer during pregnancy, see the section Injectafer and pregnancy above. Once inside your body, ferric carboxymaltose releases iron into your system. FG Trade/E+ sia Getty Images Your doctor may also recommend that you take iron supplements by mouth (if you havent tried these supplements in the past). Do not flush medications down the toilet or pour them into a drain unless instructed to do so. But you dont necessarily need to eat these foods unless your doctor tells you to do so. Hypophosphatemia seems to mostly occur in people who are already at risk for low phosphorus levels. endobj Details. A shortage of iron can cause health problems. The following information is provided for clinicians and other healthcare professionals. Depending on your doctors instructions and Some products that may interact with this drug include: vitamin products, other iron-containing products. Do not flush down a toilet or pour down a drain unless you are told to do so. There may be risks to the mother and fetus associated with untreated IDA in pregnancy. other treatments you receive, you will need to go back for several treatments with Venofer. People with IDA have low blood levels of hemoglobin. Theseside effectsmay last as long as they are undercancer treatment. What Is the Cost of Whole Genome Sequencing (WGS)? In Canada - Call your doctor for medical advice about side effects. If this happens, you may need to get another treatment course of Injectafer, if your doctor recommends it for you. Venofer (iron sucrose) is given by injection into a vein as directed by your doctor. A lack of iron can lead to iron deficiency anaemia if left untreated. Before approving coverage for Injectafer, your insurance company may require you to get prior authorization. In clinical studies, diarrhea was reported in less than 1% of people taking Injectafer. Brand-name medications usually cost more than generics. In some cases, they may even recommend that you use a drug other than Injectafer to treat your anemia. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Last reviewed . And Feraheme is approved for use in adults who have CKD who may or may not need dialysis. Hemoglobin is a protein thats found in your RBCs. . But you likely wont feel the drug working inside of you. However, not treating iron deficiency anemia during pregnancy may cause complications such as premature birth or low birth weight. This is not a list of all drugs or health problems that interact with this medicine. Once you have waited for 30 minutes after the injection, you may go home, providing you are feeling well. pain in the arms or legs. Maximum concentrations of Injectafer are achieved within 15 minutes to 1.21 hours following administration. Other drugs may interact with iron sucrose, including prescription and over-the-counter medicines, vitamins, and herbal products. Consult the product instructions and your pharmacist for storage details. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). This website is intended for use by US patients. With slow IV injection, the drug is given as a single, slow injection into your vein. Not all possible drug interactions are listed here. Serious side effects from Injectafer arent common, but they can occur. Some people may also experience skin irritation from the adhesive tape and other medical equipment used during the procedure. However, diarrhea it isnt very common in people using Injectafer. Some drugs may have another patient information leaflet. But its only approved for use in people with CKD who may or may not need dialysis. Limited data indicate that breastmilk iron is not increased after intravenous infusion of Venofer. Its responsible for carrying oxygen throughout your body. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Diarrhea. Amounts of iron ingested by the infant would be normal and are not expected to cause any adverse effects in breastfed infants. XAO$$d|0tX1`Q$Il#FBm}{#h!/;[bOvvg7 ?tMl7/+wya^,~PA}6&Ftb19OeJ6-a3acKjcpkeGq+7/nO AJJ:Okyfp;xw|]McmK?9"t0m%. Back pain. Properly discard this product when it is expired or no longer needed. You may need extra iron because of blood loss during kidney dialysis. Keep in mind that the risk of certain pregnancy-related problems can be increased if iron deficiency anemia (IDA) is left untreated. Details. The Injectafer dosage your doctor prescribes will depend on your body weight. Otherwise, call a poison control center right away. Severeside effectsmay end up causing a lot of disruption in a persons life. Allergic reactions are most likely to occur within 30 minutes of receiving Venofer. (One treatment course includes two doses of the drug.) Theseeffects of medicine on thebodycan also lead to medication non-compliance and worsening of themedical conditionthey are meant to treat. It depends. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For some people, after receiving one treatment course (two doses) of Injectafer, their IDA is resolved. Any long-term side effects/dangers from iron infusions? Examples of thisinclude: Not allside effectslast forever. In one study, people were given either Injectafer or an iron replacement drug called Venofer. Some people only need one treatment course of Injectafer. This website is intended for use by US healthcare professionals only. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Learn more about these, as well as the symptoms, diagnosis, and treatments. While the side effects that occur during treatment with these drugs are increasingly well-cataloged, the long-term side effects that may result from receiving these drugs are only beginning to be studied. It belongs to a class of medications called iron replacement products. This site is intended for use only by US patients. They can recommend if this is safe for you to do. For more information about Injectafers approved uses, see the section Injectafer uses below. Only 10 mg may be excreted by the body the next time it goes through the liver, and possibly only 5 mg the nextpass. Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. This information is not specific medical advice and does not replace information you receive from the healthcare provider. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Reactions around the injection/infusion site, such as pain, irritation, itching, bleeding, or discoloration after leakage of injection into the skin. The recommended dosing guidelines of Injectafer for treating IDA are based on patient weight, as follows: Injectafer contains ferric carboxymaltose, which is a polymer that releases iron into the body. People who weigh less than 110 lb (about 50 kg) will receive two separate Injectafer doses of 15 mg/kg of body weight. This information should not be used to decide whether or not to take Venofer or any other medicine. Infusions should be administered over at least 15 minutes. What is the latest research on the form of cancer Jimmy Carter has? Mild side effects of Injectafer can include:*. Generic name: iron sucrose (injection) [EYE-urn-SOO-krose] Injectafer isnt a medication that youll take regularly on a schedule. 2005 - 2023 WebMD LLC. Injectafer and Venofer have different approved uses, but theyre both used to treat IDA in people with CKD. In the second group, some people switched from taking iron by mouth to taking Injectafer. Its FDA-approved to treat iron deficiency anemia (IDA) in adults. Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Review our medical disclaimer. This includes your doctors, nurses, pharmacists, and dentists. Injectafer is available only as a brand-name medication. You may report side effects to FDA at 1-800-FDA-1088. Your doctor will go over your (A generic drug is an exact copy of the active drug in a brand-name medication.). experience severe side effects, please seek medical attention right away and notify the ordering physician. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The following lists contain some of the key side effects that may occur while taking Injectafer. Always review your medical history with the treatingphysician. To make sure Venofer injection is safe for you, tell your doctor if you have: hemochromatosis or iron overload (the buildup of excess iron). If a person does not have an allergic response or any other unanticipated reactions, a doctor will administer the remaining iron. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. To learn about other mild side effects, talk with your doctor or pharmacist, or see Injectafers package insert. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. The infusion concentration should not be less than 2 mg of Injectafer per mL of solution. Injectafer may not be right for you if you have certain medical conditions or other factors affecting your health. Injectafer contains the active drug ferric carboxymaltose, while Venofer contains the active drug iron sucrose. What to know about iron deficiency anemia, took oral iron treatment and didnt have improvement in their IDA or had side effects that couldnt be managed, or, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, have a medical condition that affects their bodys ability to absorb phosphorus, take medications that affect how well their, ferrous sulfate (Fer-Iron, Slow-FE, Feosol), people who took Injectafer had their hemoglobin level increase by an average of 1.1 grams per deciliter (g/dL), people who took Venofer had their hemoglobin increase by an average of 0.9 g/dL. In severe cases, it can cause asthma-like symptoms, such as wheezing and difficulty breathing. In this study, compared with their level before treatment: Injectafer isnt currently approved for use in children. But its important to note that these studies werent designed to show whether Injectafer is safe to use during pregnancy. (Hemoglobin is a protein thats found in your red blood cells.). We cancelled my 5th because of the reaction. Side effectswill last a very long time if the cause of them is not resolved. Without enough hemoglobin, the right amount of oxygen may not reach certain parts of your body.